This affects an average of 1% of the society. Unknown type 1 (MI);

The main reason is unknown, and the case is a coincidence. The prognosis is usually good and there is no need for treatment. Routine examination of unknown type 1 (PV) usually has an unknown pathology. This may be an environmental factor. The trend is worrying. Problems associated with the immune system, desidialization problems, genetic problems, uterine problems are usually the main causes and should be examined by a physician. PV with normal karyotypic abortion have a worse prognosis, whereas abnormal pregnancies with PV are more successful. Pathologies that have not been detected in the last few weeks will most likely be repeated.

In the group of elderly patients (40-44 years) the cause is not defined, and if there is no underlying pathology, the trend wants to be better.

In conclusion: In case of repeated miscarriages before the next repeated pregnancy, it is necessary to be examined, in case of miscarriage, it is recommended to take a miscarriage material for further diagnosis and genetic analysis. Pathological research is not important.

The role of clotting (thrombophilia) in recurrent abortions The role of coagulation with recurrent miscarriage (thrombophilia) Often there are recurrent miscarriages and mainly they are caused by genetic factors. These genes; depending on the genes of the mother and father: classified into heterozygous carriers and homozygous mutants.

In those who do not have homozygotes associated with this gene-associated thrombophilia, whereas homozygous mutations have thrombophilia. The conclusion of the disease usually occurs at an older age.

In genes that are heterozygous carriers; while the dominant gene is a mutant in the detection of the disease, whereas there is no recessive gene. In tests for thrombophilia, some genes are normal, and others may have a disease. When determining the presence of thrombophilia even within one day, the disease should be taken and treated.

Failure to adhere to proper treatment may be the cause of a recurrent miscarriage. Even after a second miscarriage, this treatment should be applied to subsequent pregnancies, each treatment ensures success during pregnancy. Genes that cause thrombophilia; These genes due to capillary folding prevent the attachment of the embryo to the maternal site.

In later stages, when embryo is attached, the veins leading to the embryo become clogged, preventing the development of the embryo, already in the fetal state, various abnormalities and sudden death of the fetus may occur. Because of these risks, treatment of this disease should continue during pregnancy.

PGD Preimplantation genetic diagnosis Preimplantation genetic diagnosis (PGD) is a modern method for detecting chromosomal and genetic abnormalities in the embryo before transferring it to the uterine cavity.

Even before embryo transfer to the uterus with PGD, it became possible to eliminate the risk of the birth of a child with genetic diseases associated with chromosome number violation, structural disorders in the chromosomes themselves or damage to individual genes (monogenic diseases).

In this regard, preimplantation (preimplantation) genetic diagnosis is made to patients who reached the age of 35, couples who experienced 2-3 failures in IVF 2-3 times, women who, during early pregnancy, had miscarriages and men with severe sperm production disorder.

According to statistics, those who did PGD embryos in IVF programs, are less likely to die or interrupt early. This is explained by the fact that only embryos without chromosomal and gene anomalies are selected for implantation into the uterus.